Free radical reactions for heterocycle synthesis. Part 5: Formation of novel bridged spirolactones by double cyclizations
β Scribed by Wei Zhang; Georgia Pugh
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 149 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
Novel bridged spirolactones have been synthesized via double radical cyclization of enol ester radicals.
π SIMILAR VOLUMES
Synthesis of spirodilactones is achieved by intramolecular free radical Michael addition of enol esters derivatized from tetronic acid. Synthesis of spirolactone-lactams and spirolactone-thiolactones is also covered by the scope of this new reaction.
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