Homolytic cyclization of some alkenyl fi-lactams afforded carbapenams, by exo addition, when a vicinally disubstituted double double bond was involved, and carbacephams, by endo addition, when a terminal double bond was involved. Some years ago, we described the synthesis of the (f)-1-oxacepham and
Free-radical annelation in the synthesis of bicyclic β-lactams. synthesis of 1-oxacephem and 1-oxahomocephem derivatives.
✍ Scribed by Mario D. Bachi; Christian Hoornaert
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- French
- Weight
- 196 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
A new method for the synthesis of some fused bicyclic B-lactams based on the completion of the molecular backbone by a free-radical C-C bond forming reaction is described. Many of the synthetic approaches to the fused bicyclic molecular backbone of B-lactam antibiotics are based on the annelation of
The tributyltin hydride-azobisisobutyronitrile induced cyclization of N-chloromethyl-, N-phenylselenomethyl-, and N-phenylthiomethyl-4-allyloxy-2-azetidinones to 9-oxo-6-oxa-l-azabicyclo[5.2.0]nonane is described. In the preceding communication,' we have described a new method for the synthesis of
## Abstract The synthesis of some β‐lactams and one Δ^1^‐carbapenem is described. The electronic activation of monocyclic β‐lactams of type **1** is not sufficient to generate a bioactive compound.