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Free-radical annelation in the synthesis of bicyclic β-lactams. 1. Synthesis of 8-oxo-5-oxa-1-azabicyclo[4.2.0]octane and 9-oxo-6-oxa-1-azabicyclo[5.2.0]nonane derivatives

✍ Scribed by Mario D. Bachi; Christian Hoornaert

Publisher
Elsevier Science
Year
1981
Tongue
French
Weight
199 KB
Volume
22
Category
Article
ISSN
0040-4039

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✦ Synopsis

A new method for the synthesis of some fused bicyclic B-lactams based on the completion of the molecular backbone by a free-radical C-C bond forming reaction is described. Many of the synthetic approaches to the fused bicyclic molecular backbone of B-lactam antibiotics are based on the annelation of non-fused B-lactams bearing the appropriate appendages. 192 3 In most cases this transformation is performed by a ionic-reaction. Considering the high sensi-

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