Free radical alkylation of tri-O-benzoyl-6-exo-bromo-levoglucosan: approaches to the synthesis of okadaic acid

✍ Scribed by David R Kelly; Jassem G Mahdi

• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 74 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)02181-5

✦ Synopsis

Tri-O-benzoyl-6-exo-bromo-levoglucosan undergoes stereoselective free radical alkylation to give 6-exo-substituted-1,6anhydrosugars with six contiguous chiral centres.