✦ LIBER ✦

Free flap transplantation in mice

✍ Scribed by Brian C. Cooley; Roger Daley

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 43 KB
Volume: 18
Category: Article
ISSN: 0738-1085
DOI: 10.1002/(sici)1098-2752(1998)18:5<320::aid-micr4>3.0.co;2-2

No coin nor oath required. For personal study only.

✦ Synopsis

A new model is presented that adapts the standard experimental groin free flap model to the mouse. The femoral vessels upon which the microvascular anastomoses are based are very small (0.2-0.4 mm diameter in the artery), making this a technically challenging exercise. A 100% patency was achieved for flap replantation in ICR (outbred) mice. Success rates for flap transplantation in Balb/C (syngeneic) mice rose from 20 to 75% with modification of the anastomoses from end-to-end to end-to-side procedures. This model offers new avenues of investigation when combined with recently developed transgenic mouse models.

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