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Free fatty acids in the pancreatitic arthritis syndrome

โœ Scribed by Peter A. Simkin; John D. Brunzell; David Wisner; Dr. Justus J. Fiechtner; Jeffrey S. Carlin; Robert F. Willkens

Book ID
102752721
Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
598 KB
Volume
26
Category
Article
ISSN
0004-3591

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โœฆ Synopsis

Abstract

Fat necrosis and arthritis occur in some individuals with pancreatitis. The intraarticular free fatty acid concentration was found to be markedly elevated in 2 patients with this pancreatitic arthritis syndrome. Injection of free fatty acids into rabbit knees reproduced the inflammatory synovial response including intracellular fat globules within leukocytes. Free fatty acids exceeding the available binding sites of albumin appear to mediate the extrapancreatic inflammatory manifestations of this syndrome.

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