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Fragmentation of dipyridamole and related dipyrimidines by electrospray ionization collisional activated decomposition mass spectrometry

✍ Scribed by Edson Rodrigues Filho; Adaila Marta Paixão Almeida; Marcel Tabak

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
175 KB
Volume
38
Category
Article
ISSN
1076-5174

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✦ Synopsis

Abstract

The coronary vasodilator, co‐activator of antitumor compounds and antioxidant drug dipyridamole and several of its derivatives were studied by electrospray ionization (ESI) combined with collisional activated decomposition (CAD) in both positive and negative modes. These compounds produce abundant monocharged ions ([M + H]^+^) under ESI. Interpretation of the CAD spectra showed that fragmentation occurs preferentially in the ethanolamine groups attached at C‐2, C‐4, C‐6 and C‐8. 2‐Methoxyethanol is eliminated when ethanolamines are in positions C‐2/C‐6 and 2‐aziridinethanol is eliminated from C‐4/C‐8 ethanolamines. The proposed fragmentation schemes were supported by deuterium labeling experiments and tandem mass spectrometry. Copyright © 2003 John Wiley & Sons, Ltd.

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