✦ LIBER ✦

Fragile X syndrome and acute lymphoblastic leukemia

✍ Scribed by Michael Cunningham; Joseph D. Dickerman

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 479 KB
Volume: 62
Category: Article
ISSN: 0008-543X
DOI: 10.1002/1097-0142(19881201)62:11<2383::aid-cncr2820621122>3.0.co;2-r

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✦ Synopsis

Fragile X [Fra(X)] syndrome is an example of a heritable fragility syndrome associated with mental retardation. It is characterized by a fragile site on the X chromosome at Xq27-28. There have recently been three reports of malignant solid tumors associated with Fra(X) syndrome. We describe the first case of a hematologic malignancy [T-cell acute lymphocytic leukemia (ALL)] in a patient with Fra(X) syndrome. The possibility of a predisposition to malignancy in Fra(X) is discussed.

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