Twinning and premature ovarian failure i
โ Vianna-Morgante, Angela M.
๐ Article
๐
1999
๐ John Wiley and Sons
๐ English
โ 5 KB
๐ 1 views
โฆ LIBER โฆ
Fragile X premutation is a significant risk factor for premature ovarian failure: The international collaborative POF in fragile X study?preliminary data
โ Scribed by Allingham-Hawkins, Diane J.; Babul-Hirji, Riyana; Chitayat, David; Holden, Jeanette J.A.; Yang, Kathy T.; Lee, C.; Hudson, R.; Gorwill, H.; Nolin, Sarah L.; Glicksman, Anne; Jenkins, Edmund C.; Brown, W. Ted; Howard-Peebles, Patricia N.; Becchi, Cindy; Cummings, Emilie; Fallon, Lee; Seitz, Suzanne; Black, Susan H.; Vianna-Morgante, Angela M.; Costa, Silvia S.; Otto, Paulo A.; Mingroni-Netto, Regina C.; Murray, Anna; Webb, J.; MacSwinney, F.; Dennis, N.; Jacobs, Patricia A.; Syrrou, Maria; Georgiou, Ioannis; Patsalis, Phillipos C.; Giovannucci Uzielli, Maria L.; Guarducci, S.; Lapi, E.; Cecconi, A.; Ricci, U.; Ricotti, G.; Biondi, C.; Scarselli, B.; Vieri, F.
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 44 KB
- Volume
- 83
- Category
- Article
- ISSN
- 0148-7299
- DOI
- 10.1002/(sici)1096-8628(19990402)83:4<322::aid-ajmg17>3.0.co;2-b
No coin nor oath required. For personal study only.
โฆ Synopsis
The preliminary results of an international collaborative study examining premature menopause in fragile X carriers are presented. A total of 760 women from fragile X families was surveyed about their fragile X carrier status and their menstrual and reproductive histories. Among the subjects, 395 carried a premutation, 128 carried a full mutation, and 237 were noncarriers. Sixtythree (16%) of the premutation carriers had experienced menopause prior to the age of 40 compared with none of the full mutation carriers and one (0.4%) of the controls. Based on these preliminary data, there is a significant association between fragile X premutation carrier status and premature menopause.
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