Fragile sites induced by FUdR, caffeine, and aphidicolin
โ Scribed by P. Nagesh Rao; Nyla A. Heerema; Catherine G. Palmer
- Publisher
- Springer
- Year
- 1988
- Tongue
- English
- Weight
- 492 KB
- Volume
- 78
- Category
- Article
- ISSN
- 0340-6717
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Chromosome fragile sites are inducible by aphidicolin in cultured human lymphocytes. To assess the frequency and distribution of these common fragile sites in the general population, a cytogenetic survey was performed on 126 subjects, 59 males and 67 females, whose age ranged from 1 day to 72 years.
A correlation between specific fragile sites and cancer breakpoints has been suggested raising the question of fragile site expression as a predisposing factor in the occurrence of cancer in some persons. Before addressing the question of increased fragility among patients at high risk for cancer, w
Aphidicolin, a specific inhibitor of DNA polymerase alpha, is known to induce chromosomal aberrations. At concentrations that did not greatly affect mitotic index, aphidicolin induced a striking number of chromosome gaps and breaks distributed in a highly nonrandom manner in cultured human lymphocyt
In this study, the effect of pyrimethamine in inducing expression of fragile sites in human peripheral blood lymphocyte cultures is investigated. In vitro lymphocyte cultures of 15 healthy individuals were treated with 0.02 mg/ml of pyrimethamine for 48 and 72 hr. One culture was used as control. Th