Fragile sites and structural rearrangements in cancer
β Scribed by M. Braekeleer; B. Smith; C. C. Lin
- Publisher
- Springer
- Year
- 1985
- Tongue
- English
- Weight
- 494 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0340-6717
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The expression of common fragile sites induced by aphidicolin and caffeine was evaluated on prometaphase obtained from the peripheral blood lymphocytes of 35 women with breast cancer, their 35 clinically healthy female family members, and 20 sex-and age-matched normal controls. As a result of the cy
## Abstract The common fragile site, FRA3B, has been shown to be a site of frequent homozygous deletions in some cancers, resulting in loss of expression of the associated __FHIT__ gene. It has been proposed that __FHIT__ is a tumor suppressor gene that is inactivated as a result of the instability