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FR901228, a Potent Antitumor Antibiotic, Is a Novel Histone Deacetylase Inhibitor

✍ Scribed by Hidenori Nakajima; Young Bae Kim; Hiroshi Terano; Minoru Yoshida; Sueharu Horinouchi

Book ID
115602947
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
212 KB
Volume
241
Category
Article
ISSN
0014-4827

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## Abstract Histone deacetylase (HDAC) inhibitors are among the most promising targeted anticancer agents and are potent inducers of growth arrest, differentiation, and/or apoptotic cell death of transformed cells. In this study, antitumor effects of a novel sulfur‐containing hydroxamate HDAC inhib