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FPipTB, a benzimidazole derivative, induces chondrosarcoma cell apoptosis via endoplasmic reticulum stress and apoptosis signal-regulating kinase 1

✍ Scribed by Ju-Fang Liu; Chih-Shiang Chang; Yi-Chin Fong; Sheng-Chu Kuo; Chih-Hsin Tang

Book ID
112142281
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
578 KB
Volume
51
Category
Article
ISSN
0899-1987

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## Abstract Chondrosarcoma is a malignant primary bone tumor that responds poorly to both chemotherapy and radiation therapy. The aim of this study was to elucidate the mechanism of the novel Combretastatin A‐4 derivative, 2‐(furanyl)‐5‐(pyrrolidinyl)‐1‐(3,4,5‐trimethoxybenzyl)benzoimidazole (FPTB)