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Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

✍ Scribed by Ono, Masahiro; Yaguchi, Hiroko; Ohkura, Naganari; Kitabayashi, Issay; Nagamura, Yuko; Nomura, Takashi; Miyachi, Yoshiki; Tsukada, Toshihiko; Sakaguchi, Shimon


Book ID
109896584
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
679 KB
Volume
446
Category
Article
ISSN
0028-0836

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Mutations of forkhead box p3 (__FOXP3__), the master gene for naturally occurring regulatory T cells (nTregs), are responsible for the impaired function of nTregs, resulting in an autoimmune disease known as the immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome. The rel