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Four human Chromosome 3q and four human Chromosome 21 loci map onto sheep Chromosome 1q

✍ Scribed by T. E. Broad; D. J. Burkin; L. M. Cambridge; P. E. Lewis; D. W. Maher; H. A. Ansari; P. D. Pearce; C. Jones

Publisher: Springer-Verlag
Year: 1995
Tongue: English
Weight: 571 KB
Volume: 6
Category: Article
ISSN: 0938-8990
DOI: 10.1007/bf00293014

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✦ Synopsis

Eight new loci have been assigned to sheep Chromosome (Chr) 1q by use of a chromosomally characterized minipanel of sheep x hamster cell hybrids. Four loci, which have been mapped to the distal region of human Chr 3q, are ceruloplasmin (CP), sucrase isomaltase (SI), glucose transporter 2 (GLUT2), and ectopic viral integration site 1 (EVI1). The other four loci, on human Chr 21, include interferon alpha receptor (IFNAR); interferon inducible protein p78, murine (MX1); collagen type VI, alpha 1 (COL6A1); and S100 protein, beta polypeptide (S100B). All of these loci, except GLUT2 and MX1, have been mapped onto bovine Chr 1 or are syntenic with loci on this chromosome. The in situ localization of transferrin (TF) to sheep Chr 1q42-q45 confirms our previous assignment of this locus and independently anchors the eight new syntenic loci to sheep Chr 1q.

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