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Fosmidomycin, a specific inhibitor of 1-deoxy-d-xylulose 5-phosphate reductoisomerase in the nonmevalonate pathway for terpenoid biosynthesis

✍ Scribed by Tomohisa Kuzuyama; Tomohiro Shimizu; Shunji Takahashi; Haruo Seto


Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
231 KB
Volume
39
Category
Article
ISSN
0040-4039

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1-Deoxy-D-xyluiose 5-phosphate is biotransformed to 2-C-methyl-D-erythritol 4-phosphate in a single step in the presence of NADPH by a new recombinant enzyme named l-deoxy-D-xylulose 5-phosphate reductoisomerase purified from Escherichia coli.