Formosalides A and B, cytotoxic 17-membered ring macrolides from a marine dinoflagellate Prorocentrum sp.

✍ Scribed by Chung-Kuang Lu; Yi-Min Chen; Siang-Hang Wang; Ying-Yan Wu; Ying-Min Cheng

• Book ID: 104096268
• Publisher: Elsevier Science
• Year: 2009
• Tongue: French
• Weight: 327 KB
• Volume: 50
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2009.02.013

✦ Synopsis

Formosalides A (1) and B (2), two novel cytotoxic 17-membered ring macrolides with all-cis tetraenes, a tetrahydropyran ring, and a tetrahydrofuran ring, were isolated from the cultured marine dinoflagellate Prorocentrum sp. Their gross structures, including local relative stereostructures, were elucidated by extensive spectroscopic studies.