Formation of the Nonproteinogenic Amino Acid 2S,3R-Capreomycidine by VioD from the Viomycin Biosynthesis Pathway
โ Scribed by Xihou Yin; Kerry L. McPhail; Kyung-ja Kim; T. Mark Zabriskie
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 156 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1439-4227
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The N-Boc dihydroxyethylene dipeptide isostere 7 and its N-Boc 3-(thiazol-4-ylJalany1 derivative 8 were synthesized, without purification of intermediates, from (4S~R)-22-dimethyl-4-(2-methy~propylJ-5-hydro~~thyl-l.3-dioxolane (361, in 24 and 32% overall yield, respectively, Alcohol 38 was readily p