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Formation of Ganglioside GD 1b-Lactone in Rat Brain from Intracisternally Administered GD 1b

✍ Scribed by Laura Riboni; Riccardo Ghidoni; Guido Tettamanti


Book ID
111175316
Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
622 KB
Volume
52
Category
Article
ISSN
0022-3042

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ABSTRACX Gangliosides that contain the disialosyl residue a-NeuSAc-(2-+8)-a-NeuSAc-(2+3)-can lactonize in the presence of traces of acid and this reaction has been studied in detail on GDlb {~-Gal-(1+3)-/3-GalNAc-(l-+4)-[cY-NeuSAc-(2-+8)-~-NeuSAc-(2+3)]+Gal-( l-+4)-/3-Glc-(l-+1)-Cer}. Lactonization

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We have studied the cellular distribution of gangliosides GD1b, GD3 and GM1 in rat cerebellum by immunostaining, using monoclonal antibodies and confocal microscopy. Antibodies against astroglial, neuronal and synaptic vesicle associated molecules were used for colocalization analyses. In the gray m