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Formation of DNA-protein cross-linkages and their possible elimination by mustine in cultures of normal human fibroblasts

✍ Scribed by V. V. Rupasov; V. I. Kukharenko; A. I. Gorin; K. N. Grinberg; P. I. Tseitlin


Publisher
Springer US
Year
1978
Tongue
English
Weight
367 KB
Volume
86
Category
Article
ISSN
0007-4888

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Levels of DNA strand breaks and DNA-protein cross-links (DPCs) were measured using the alkaline elution assay in normal human skin fibroblasts irradiated with 0-200 J m-2 of 254 nm UV radiation and incubated for 0-24 h. On incubation, the yields of both single-strand breaks (SSBs) and DPCs increased