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Formation of DNA adduct by MeIQx: relation between administration dose and adduct level

✍ Scribed by M. Hirose; K. Takayama; K. Wakabayashi; T. Sugimura; M. Nagao

Book ID
113252351
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
177 KB
Volume
252
Category
Article
ISSN
0165-1161

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2-14 C]2-amino-3,8-dimethylimidazo[4,5-f ]quinoxaline (MeIQx) was administered orally (304 ng/kg body-weight dose based upon an average 70-kg-body-weight subject) to 5 human colon-cancer patients (58 to 84 years old), as well as to F344 rats and B 6 C 3 F 1 mice. Colon tissue was collected from the