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Formation of benzo[a]pyrene-DNA adducts in blood monocytes from lung cancer patients with a familial history of lung cancer

✍ Scribed by Dennis Nowak; Andreas Meyer; Ute Schmidt-Preuss; Ulrich Gatzemeier; Helgo Magnussen; Hugo W. Rüdiger


Book ID
112495624
Publisher
Springer-Verlag
Year
1992
Tongue
English
Weight
475 KB
Volume
118
Category
Article
ISSN
1432-1335

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DNA adducts are mainly detected by 32 P-postlabeling and enzyme-linked immunosorbent assays. We have established a method for detection of benzo[a]pyrene-diol-epoxide (BPDE)-DNA adducts by flow cytometry, and have clarified the effects of the DNA adducts on cell-cycle progression and the relationshi