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Formation of acyclic and cyclic guanine adducts in DNA reacted with .alpha.-acetoxy-N-nitrosopyrrolidine

✍ Scribed by Wang, Mingyao; Chung, Fung Lung; Hecht, Stephen S.


Book ID
127206583
Publisher
American Chemical Society
Year
1989
Tongue
English
Weight
719 KB
Volume
2
Category
Article
ISSN
0893-228X

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The treatment of guanine nucleosides and nucleotides with excess acetaldehyde in pH 8.0 phosphate buffer containing a basic amino acid such as arginine and lysine resulted in the smooth and selective formation of the corresponding cyclic 1,N 2 -propano adducts even under mild conditions.