Formation and persistence of DNA adducts of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in CDF1 mice fed a high ω-3 fatty acid diet
✍ Scribed by Herman A.J Schut; Chang-Lin Wang; Lisa M Twining; Kim M Earle
- Book ID
- 114071295
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 262 KB
- Volume
- 378
- Category
- Article
- ISSN
- 0027-5107
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2-Amino-1-methyl-6-phenylimidazo[4,5b]pyridine (PhIP) and 2-amino-3-methylimidazo[4,5f]quinoline (IQ) are two important heterocyclic amines formed in proteinaceous foods during the cooking process. Both PhIP and IQ are carcinogenic in several strains of rats. PhIP induces mammary tumors in female F3
## Abstract 2‐Amino‐3‐methylimidazo[4,5‐__f__]quinoline (IQ) and 2‐amino‐3,8‐dimethylimidazo[4,5‐__f__]quinoxaline (MelQx) are carcinogens found in cooked meats that form DNA adducts upon metabolic activation. Purified DNA from Chinese hamster ovary (CHO) cells was reacted in vitro with the active
## Abstract 2‐Amino‐3‐methylimidazo[4,5‐f]quinoline (IQ) and 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐__b__)]pyridine (PhIP) are two members of a family of carcinogenic heterocyclic amines (HAs) found in cooked meats that form DNA adducts after activation to __N__‐acetoxy derivatives. The ability of IQ