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Formation and persistence of DNA adducts of 2-amino-3-methylimidazo[4,5-f]quinoline in the rat and nonhuman primates

✍ Scribed by Robert J Turesky; Rafael Munoz Box; Jovanka Markovic; Eric Gremaud; Elizabeth G Snyderwine

Book ID: 114071252
Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 363 KB
Volume: 376
Category: Article
ISSN: 0027-5107
DOI: 10.1016/s0027-5107(97)00048-1

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2-Amino-1-methyl-6-phenylimidazo[4,5b]pyridine (PhIP) and 2-amino-3-methylimidazo[4,5f]quinoline (IQ) are two important heterocyclic amines formed in proteinaceous foods during the cooking process. Both PhIP and IQ are carcinogenic in several strains of rats. PhIP induces mammary tumors in female F3