Formal Syntheses of Dihydrocorynantheine and Isorhynchophylline via Proline Catalyzed Mannich-Michael Reaction
✍ Scribed by Itoh, Takashi; Ishikawa, Hitomi; Tanaka, Ayako; Miyazaki, Michiko; Kanemitsu, Takuya; Nagata, Kazuhiro
- Book ID
- 118245271
- Publisher
- Japan Institute of Heterocyclic Chemistry
- Year
- 2010
- Tongue
- English
- Weight
- 675 KB
- Volume
- 81
- Category
- Article
- ISSN
- 0385-5414
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## Abstract The domino Mannich/aza‐Michael reaction of γ‐malonate‐substituted α,β‐unsaturated esters with __N__‐protected arylaldimines has been achieved. Catalyzed by bifunctional thioureas, 2,5‐__cis__‐configured polysubstituted pyrrolidines are obtained in good to excellent yields (76–99%), enan