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Formal Nucleophilic Substitution of Bromocyclopropanes with Amides en route to Conformationally Constrained β-Amino Acid Derivatives

✍ Scribed by Prosser, Anthony R.; Banning, Joseph E.; Rubina, Marina; Rubin, Michael

Book ID
111879604
Publisher
American Chemical Society
Year
2010
Tongue
English
Weight
691 KB
Volume
12
Category
Article
ISSN
1523-7060

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📜 SIMILAR VOLUMES

ChemInform Abstract: Formal Nucleophilic
ChemInform Abstract: Formal Nucleophilic Substitution of Bromocyclopropanes with Amides en route to Conformationally Constrained β-Amino Acid Derivatives.
✍ Anthony R. Prosser; Joseph E. Banning; Marina Rubina; Michael Rubin 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 44 KB 👁 1 views

## Abstract A wide range of trans‐β‐aminocyclopropane carboxylic acid derivatives is prepared with the highest yields being observed for the 4‐(trifluoromethyl)‐ or 3,5‐bis‐(trifluoromethyl) benzoic acid amides.

Nucleophilic substitution of protected 2
Nucleophilic substitution of protected 2-amino-4-butanoic acid. An easy route to exotic amino acids and conformationally constrained peptides
✍ Paola Ciapetti; André Mann; Angèle Shoenfelder; Maurizio Taddei 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 211 KB

The synthesis of a series of novel (t-amino acids based on the nucleophilic substitution of protected 2-amino-4-bromobutanoic acid (1) is described. Basic, acidic or neutral amino acids can be obtained; chimerical amino acids carrying a coenzyme type structure in the side chain, multifunctional amin