Forces involved in the Conformational Stability of Nucleic Acids
โ Scribed by MAURIZOT, J. C.; BRAHMS, J.; ECKSTEIN, F.
- Book ID
- 109667330
- Publisher
- Nature Publishing Group
- Year
- 1969
- Tongue
- English
- Weight
- 371 KB
- Volume
- 222
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/222559a0
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๐ SIMILAR VOLUMES
## Abstract __Intercalating nucleic acids (INAยฎs) with insertions of (__R__)โ1โ__O__โ(1โpyrenylmethyl)glycerol were hybridized with locked nucleic acids (LNAs). INA/LNA duplexes were found to be less stable than the corresponding DNA/LNA duplexes when the INA monomer was inserted as a bulge close t
We have used 2D NMR spectroscopy to study the sugar conformations of oligonucleotides containing a conformationally restricted nucleotide (LNA) with a 2'-O, 4'-C-methylene bridge. We have investigated a modified 9-mer single stranded oligonucleotide as well as three 9-and 10-mer modified oligonucleo