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Cover Picture: Locked Nucleic Acids and Intercalating Nucleic Acids in the Design of Easily Denaturing Nucleic Acids: Thermal Stability Studies (ChemBioChem 12/2004)

✍ Scribed by Vyacheslav V. Filichev; Ulf B. Christensen; Erik B. Pedersen; B. Ravindra Babu; Jesper Wengel

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
23 KB
Volume
5
Category
Article
ISSN
1439-4227

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Locked Nucleic Acids and Intercalating N
Locked Nucleic Acids and Intercalating Nucleic Acids in the Design of Easily Denaturing Nucleic Acids: Thermal Stability Studies
✍ Vyacheslav V. Filichev; Ulf B. Christensen; Erik B. Pedersen; B. Ravindra Babu; 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 168 KB 👁 1 views

## Abstract __Intercalating nucleic acids (INA®s) with insertions of (__R__)‐1‐__O__‐(1‐pyrenylmethyl)glycerol were hybridized with locked nucleic acids (LNAs). INA/LNA duplexes were found to be less stable than the corresponding DNA/LNA duplexes when the INA monomer was inserted as a bulge close t

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✍ Raffaele Saladino; Claudia Crestini; Umberto Ciambecchini; Fabiana Ciciriello; G 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 24 KB

**The cover picture shows** the synthesis of several components of nucleic acids in prebiotic conditions. Purine, __N__^9^‐formylpurine, adenine, cytosine, uracil, hypoxanthine and several intermediates of the inosine pathway are obtained in “one‐pot” synthesis by heating a one‐carbon‐atom fragment,