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Force and stiffness of old dystrophic (mdx) mouse skeletal muscles

✍ Scribed by Jacques Bobet; Robert F. Mooney; Tessa Gordon

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 92 KB
Volume: 21
Category: Article
ISSN: 0148-639X
DOI: 10.1002/(sici)1097-4598(199804)21:4<536::aid-mus15>3.0.co;2-v

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✦ Synopsis

It has recently been suggested, based on studies of tissue pathology, that the limb muscles of old mdx mice may be a good model for the muscular changes seen in human Duchenne muscular dystrophy. To test this hypothesis, we measured force and stiffness of soleus and extensor digitorum longus (EDL) muscles of old (20-21 months) mdx mice and agematched controls. The mdx and control muscles generated similar twitch, tetanic, and eccentric forces. They were also equally stiff. The results show that the mechanics of aged mdx limb muscles differ greatly from Duchenne muscular dystrophy in humans, and disagree with the hypothesis.

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## ABSTRACT The mdx mouse has been used as an animal model for human Duchenne muscular dystrophy (DMD). Unlike DMD, skeletal muscles of mdx mice undergo successful regeneration and do not show extensive fibrosis and functional impairment. Growth factors have been proposed to be involved in muscle g