Duchenne muscular dystrophy is an X-linked devastating disease due to the lack of expression of a functional dystrophin. Unfortunately, the dystrophin-deficient mdx mouse model does not present clinical signs of dystrophy before the age of 18 months, and the role of dystrophin in fiber integrity is
Effects of exercise and steroid on skeletal muscle apoptosis in the mdx mouse
β Scribed by Jeong-Hoon Lim; Dai-Youl Kim; Moon Suk Bang
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 205 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0148-639X
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We have studied the in vitro contractile and fatigue characteristics of extensor digitorum longus (EDL) muscles from 8- and 62-week-old dystrophin-deficient (mdx) and control mice at 20 degrees C and 35 degrees C. There were no differences in fatigability at 20 degrees C, but at 35 degrees C the dys
## Abstract Ceramide is the key compound on crossroads of sphingolipid metabolism. The content and composition of ceramides in skeletal muscles have been shown to be affected by prolonged exercise. The aim of this study was to examine the effect of exercise on the activity of key enzymes of ceramid