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Follistatin-like protein 1 enhances NLRP3 inflammasome-mediated IL-1β secretion from monocytes and macrophages

✍ Scribed by Chaly, Yury; Fu, Yu; Marinov, Anthony; Hostager, Bruce; Yan, Wei; Campfield, Brian; Kellum, John A.; Bushnell, Daniel; Wang, Yudong; Vockley, Jerry; Hirsch, Raphael

Book ID
121843810
Publisher
John Wiley and Sons
Year
2014
Tongue
English
Weight
607 KB
Volume
44
Category
Article
ISSN
0014-2980

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✍ Luigi Franchi; Gabriel Núñez 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 175 KB

## Abstract Aluminum hydroxide (alum) is the most widely used adjuvant in human vaccines, but the immune mechanisms that are activated by alum remain poorly understood. Alum has recently been shown to promote caspase‐1 activation and IL‐1β secretion, but the cellular pathways involved remain elusiv