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Sphingosine regulates the NLRP3-inflammasome and IL-1β release from macrophages

✍ Scribed by Nadia M. Luheshi; James A. Giles; Gloria Lopez-Castejon; David Brough

Book ID
102166164
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
431 KB
Volume
42
Category
Article
ISSN
0014-2980

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✍ Luigi Franchi; Gabriel Núñez 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 175 KB

## Abstract Aluminum hydroxide (alum) is the most widely used adjuvant in human vaccines, but the immune mechanisms that are activated by alum remain poorly understood. Alum has recently been shown to promote caspase‐1 activation and IL‐1β secretion, but the cellular pathways involved remain elusiv