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Folic acid reduces efficacy of methotrexate in rheumatoid arthritis

Book ID
120851605
Publisher
Adis International Limited (now part of Wolters Kluwer Health)
Year
2005
Weight
120 KB
Volume
&NA;
Category
Article
ISSN
1173-8324

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The effect of folic acid and folinic aci
The effect of folic acid and folinic acid supplements on purine metabolism in methotrexate-treated rheumatoid arthritis
✍ Sarah L. Morgan; Robert A. Oster; Jeannette Y. Lee; Graciela S. AlarcΓ³n; Joseph πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 97 KB πŸ‘ 2 views

## Abstract ## Objective To determine if folinic acid supplementation during methotrexate (MTX) therapy for rheumatoid arthritis (RA) reduces both urinary 5‐aminoimidazole‐4‐carboxamide (AICA) and urinary adenosine excretion more than does folic acid supplementation. AICA and adenosine are markers

Cochrane Database of Systematic Reviews
Cochrane Database of Systematic Reviews (Reviews) || Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis
✍ Shea, Beverley πŸ“‚ Article πŸ“… 2013 πŸ› Wiley (John Wiley & Sons) 🌐 English βš– 526 KB

## Background: Methotrexate (mtx) is a disease modifying antirheumatic drug (dmard) used as a first line agent for treating rheumatoid arthritis (ra). pharmacologically, it is classified as an antimetabolite due to its antagonistic effect on folic acid metabolism. many patients treated with mtx exp