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Folic acid mediated attenuation of loss of heterozygosity of DCC tumor suppressor gene in the colonic mucosa of patients with colorectal adenomas

✍ Scribed by Kiran K Nagothu; Richard Jaszewski; Lathika Moragoda; Arun K Rishi; Raphaela Finkenauer; Martin Tobi; Jo Ann Naumoff; Ravi Dhar; Murray Ehrinpreis; Omer Kucuk; Adhip P.N Majumdar

Book ID: 114238180
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 174 KB
Volume: 27
Category: Article
ISSN: 0361-090X
DOI: 10.1016/s0361-090x(03)00100-4

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## BACKGROUND. The majority of colorectal carcinomas, if not all, arise from a benign adenoma. The DNA of the carcinomatous cells frequently has mutations in several genes. However, it is not exactly clear when during the neoplastic process each mutation develops. An adenoma with an area of in sit