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Folic acid analogs. I. p-[[(2,4-Diamino-5-pyrimidinyl)methyl]amino]benzoyl-L-glutamic acid and related compounds

✍ Scribed by Weinstock, Louis T.; O'Brien, Darrell E.; Cheng, C. C.


Book ID
126876282
Publisher
American Chemical Society
Year
1968
Tongue
English
Weight
473 KB
Volume
11
Category
Article
ISSN
0022-2623

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## Abstract A simple and general method for the synthesis of folate analogs labeled in the glutamate moiety with ^14^C is described. The synthesis makes use of the trimethylsilyl derivative of L‐glutamic acid 8 for the coupling reaction with the activated pteroate analogs. Deprotection under mild c