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Folding Mechanism of a Precursor Protein of a Peptide Hormone Mediated by an Intra-Molecular Chaperone

โœ Scribed by Okumura, Masaki; Yoshida, Yu-ichiro; Yamaguchi, Hiroshi; Hidaka, Yuji


Book ID
119209595
Publisher
Biophysical Society
Year
2012
Tongue
English
Weight
38 KB
Volume
102
Category
Article
ISSN
0006-3495

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## Abstract Alternate frame folding (AFF) is a mechanism by which conformational change can be engineered into a protein. The protein structure switches from the wildโ€type fold (__N__) to a circularlyโ€permuted fold (__N__โ€ฒ), or vice versa, in response to a signaling event such as ligand binding. De