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Folding and dimerization of hepatitis C virus E1 and E2 glycoproteins in stably transfected CHO cells

✍ Scribed by Michela Brazzoli; Ari Helenius; Steven K.H. Foung; Michael Houghton; Sergio Abrignani; Marcello Merola

Book ID
113946228
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
848 KB
Volume
332
Category
Article
ISSN
0042-6822

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## Abstract HepG2 cells stably transfected with a full‐length, infectious hepatitis C virus (HCV) cDNA demonstrated consistent replication of HCV for more than 3 years. Intracellular minus strand HCV RNA was present. Minus strand synthesis was NS5B dependent, and was sensitive to interferon alpha (