Association of antibodies to hepatitis C virus glycoproteins 1 and 2 (anti-E1E2) with HCV disease
β Scribed by M. R. B. Hamed; A. W. Tarr; C. P. McClure; J. K. Ball; T. P. Hickling; W. L. Irving
- Book ID
- 108886100
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 171 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1352-0504
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The second envelope protein (E2) of the hepatitis C virus (HCV) was cloned and expressed in Chinese hamster ovary (CHO) cells. This E2 glycoprotein was purified using ion exchange and lectin chromatography and used to construct an enzyme immunoassay for HCV E2 antibodies. The assay was shown to have
## Abstract The dynamic features of three specific antiβhepatitis C virus (HCV) antibody subpopulations directed against different conformational epitopes of the viral E2 protein (HCV/E2) have been evaluated in patients with primary and persistent HCV infection; the three subpopulations are present