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Fold up or perish: unfolded protein response and chemotherapy

โœ Scribed by Strasser, A; Puthalakath, H

Book ID
110017564
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
86 KB
Volume
15
Category
Article
ISSN
1350-9047

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## Abstract Heterologous protein expression can easily overwhelm a cell's capacity to properly fold protein, initiating the unfolded protein response (UPR), and resulting in a loss of protein expression. In the current model of the UPR, the chaperone BiP modulates the activation of the UPR due to i