Homology or comparative modeling is aimed at modeling the three-dimensional structure of a target sequence of unknown structure using the framework of an already known fold. Traditionally, homology modeling has been applied to targets with clear sequence similarity to proteins of known structure. Be
Fold assignments for amino acid sequences of the CASP2 experiment
โ Scribed by Rice, Danny W.; Fischer, Daniel; Weiss, Robert; Eisenberg, David
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 199 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0887-3585
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โฆ Synopsis
New and newly extended methods for fold assignment were tested for their abilities to assign folds to amino acid target sequences of unknown three-dimensional structure. These target sequences, released through the CASP2 experiment, are not obviously related to any sequence of known three-dimensional (3D) structure. We assigned 3D folds to target sequences and filed these predictions with CASP2 before their 3D structures were released. The methods tested were (1) Environmental 3D profiles of Bowie and colleagues [Bowie, J.U.
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