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Folate metabolic gene polymorphisms and childhood acute lymphoblastic leukemia: a case–control study

✍ Scribed by Gast, A; Bermejo, J L; Flohr, T; Stanulla, M; Burwinkel, B; Schrappe, M; Bartram, C R; Hemminki, K; Kumar, R


Book ID
110056990
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
109 KB
Volume
21
Category
Article
ISSN
0887-6924

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The interindividual variation in the activity of xenobiotic metabolizing enzymes and DNA repair genes could modify an individual's risk of recurrent malignancy and response to therapy. We investigated whether ALL outcome was related to polymorphisms in genes CYP2D6, MPO, EPHX1, NQO1, TS, XPD and XRC