Foemylation of 2,3-dihydro-4-methyl-1h-1,5-benzodiazepin-2-ones
β Scribed by V. N. Proshkina; Z. F. Solomko; N. Ya. Bozhanova
- Publisher
- Springer US
- Year
- 1988
- Tongue
- English
- Weight
- 61 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0009-3122
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In the title compound, C 22 H 18 C l2 N 2 , the seven-membered heterocyclic ring is in a boat-shaped conformation. The molecules are linked by N-HΓ Γ ΓN hydrogen bonding into one-dimensional chains along the [010] direction.
## Abstract Two benzodiazepines, Diazepam and Flunitrazepam, labeled with carbonβ14 in position 5 of the diazepine ring have been synthesized. Use of a condensation between iminochlorides and ^14^Cβbenzonitriles, followed by exhaustive methylation of the resulting quinazolines and hydrolyses is des
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