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2,4-Bis(4-chlorophenyl)-2-methyl-2,3-dihydro-1H-1,5-benzodiazepine

โœ Scribed by An, Li-Tao ;Ding, Fei-Qing ;Zou, Jian-Ping ;Lu, Xiao-Hua


Publisher
International Union of Crystallography
Year
2007
Tongue
English
Weight
989 KB
Volume
63
Category
Article
ISSN
1600-5368

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โœฆ Synopsis


In the title compound, C 22 H 18 C l2 N 2 , the seven-membered heterocyclic ring is in a boat-shaped conformation. The molecules are linked by N-Hร ร รN hydrogen bonding into one-dimensional chains along the [010] direction.


๐Ÿ“œ SIMILAR VOLUMES


4,4-Dimethyl-4,5-dihydro-1H-1,5-benzodia
โœ Rashid, Naghmana ;Hasan, Mashooda ;Yusof, Nurdiyana M. ;Yamin, Bohari M. ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› International Union of Crystallography ๐ŸŒ English โš– 289 KB

In the title compound, C 11 H 14 N 2 O, the diazepine ring adopts a skewed boat conformation. The molecule is stabilized by N-Hร ร รO intermolecular hydrogen bonds, forming a zigzag chain parallel to the b axis.

The preparation of 7-chloro-5-(2-chlorop
โœ H. H. Kaegi; W. Burger ๐Ÿ“‚ Article ๐Ÿ“… 1982 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 168 KB ๐Ÿ‘ 1 views

## Abstract 7โ€Chloroโ€5โ€(2โ€chlorophenyl)โ€1,3โ€dihydroโ€2Hโ€1,4โ€benzodiazepinโ€2โ€one labeled with carbonโ€14 in carbon 5 of the diazepine ring has been synthesized. The compound was prepared in a multistep synthesis from barium carbonateโ€^14^C in an overall yield of 23%.

The synthesis of 7-chloro-1-methyl-5-phe
โœ H. H. Kaegi; W. Burger; C. J. Bader ๐Ÿ“‚ Article ๐Ÿ“… 1982 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 393 KB ๐Ÿ‘ 1 views

## Abstract Two benzodiazepines, Diazepam and Flunitrazepam, labeled with carbonโ€14 in position 5 of the diazepine ring have been synthesized. Use of a condensation between iminochlorides and ^14^Cโ€benzonitriles, followed by exhaustive methylation of the resulting quinazolines and hydrolyses is des