2,4-Bis(4-chlorophenyl)-2-methyl-2,3-dihydro-1H-1,5-benzodiazepine
โ Scribed by An, Li-Tao ;Ding, Fei-Qing ;Zou, Jian-Ping ;Lu, Xiao-Hua
- Publisher
- International Union of Crystallography
- Year
- 2007
- Tongue
- English
- Weight
- 989 KB
- Volume
- 63
- Category
- Article
- ISSN
- 1600-5368
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โฆ Synopsis
In the title compound, C 22 H 18 C l2 N 2 , the seven-membered heterocyclic ring is in a boat-shaped conformation. The molecules are linked by N-Hร ร รN hydrogen bonding into one-dimensional chains along the [010] direction.
๐ SIMILAR VOLUMES
In the title compound, C 11 H 14 N 2 O, the diazepine ring adopts a skewed boat conformation. The molecule is stabilized by N-Hร ร รO intermolecular hydrogen bonds, forming a zigzag chain parallel to the b axis.
## Abstract 7โChloroโ5โ(2โchlorophenyl)โ1,3โdihydroโ2Hโ1,4โbenzodiazepinโ2โone labeled with carbonโ14 in carbon 5 of the diazepine ring has been synthesized. The compound was prepared in a multistep synthesis from barium carbonateโ^14^C in an overall yield of 23%.
## Abstract Two benzodiazepines, Diazepam and Flunitrazepam, labeled with carbonโ14 in position 5 of the diazepine ring have been synthesized. Use of a condensation between iminochlorides and ^14^Cโbenzonitriles, followed by exhaustive methylation of the resulting quinazolines and hydrolyses is des