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Fluorocitrate and fluoroacetate effects on astrocyte metabolism in vitro

✍ Scribed by Raymond A. Swanson; Steven H. Graham

Book ID
113127277
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
686 KB
Volume
664
Category
Article
ISSN
0006-8993

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Fluoroacetate and its toxic metabolite fluorocitrate cause inhibition of aconitase. In brain tissue, both substances are preferentially taken up by glial cells and leads to inhibition of the glial TCA cycle. It is important to realise, however, that the glia-specificity of these compounds depends bo