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Fluoroanalogues of anti-Cytomegalovirus Agent Cyclopropavir: Synthesis and Antiviral Activity of (E)- and (Z)-9-{[2,2-Bis(hydroxymethyl)-3-fluorocyclopropylidene] methyl}-adenines and Guanines.

โœ Scribed by Shaoman Zhou; Jiri Zemlicka; Earl R. Kern; John C. Drach


Book ID
102003752
Publisher
John Wiley and Sons
Year
2007
Weight
18 KB
Volume
38
Category
Article
ISSN
0931-7597

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โœ Yoshiko Kikuchi; Hiroko Kurata; Shigeru Nishiyama; Shosuke Yamamura; Kuniki Kato ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 217 KB

The enantiomerically pure synthesis of 9-[2',3'-dideoxy-2',3'-bis-C-hydroxymethyl-c~-Lthreofuranosyl]adenine and its 4'-thio analog was achieved via coupling of silylated 6-chloropurine with l-O-acetylfuranose derivative 17 and its 4'-thio analog 24, respectively, prepared from (+)-diethyl Ltartrate