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Synthesis of 9-[2′,3′-dideoxy-2′,3′-bis-C-hydroxymethyl-α-l-threofuranosyl]adenine and its 4′-thio analog as potential antiviral agents

✍ Scribed by Yoshiko Kikuchi; Hiroko Kurata; Shigeru Nishiyama; Shosuke Yamamura; Kuniki Kato

Book ID: 104257392
Publisher: Elsevier Science
Year: 1997
Tongue: French
Weight: 217 KB
Volume: 38
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(97)01035-6

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✦ Synopsis

The enantiomerically pure synthesis of 9-[2',3'-dideoxy-2',3'-bis-C-hydroxymethyl-c~-Lthreofuranosyl]adenine and its 4'-thio analog was achieved via coupling of silylated 6-chloropurine with l-O-acetylfuranose derivative 17 and its 4'-thio analog 24, respectively, prepared from (+)-diethyl Ltartrate.

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