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Fluoro-substituted ketones from nitriles using acidic and basic reaction conditions

✍ Scribed by Erum K. Raja; Douglas A. Klumpp


Book ID
113929808
Publisher
Elsevier Science
Year
2011
Tongue
French
Weight
766 KB
Volume
52
Category
Article
ISSN
0040-4039

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ChemInform Abstract: Reaction of Phospho
✍ B. Camuzat-Dedenis; O. Provot; H. Moskowitz; J. Mayrargue πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 32 KB πŸ‘ 1 views

The title method for the synthesis of acetophenones of type (III), obtained in fair to good yields, is a good alternative to organometallic reactions. Lithium chloride, generated by deprotonation of the phosphonium salt with PhLi as base, probably acts as a Lewis acid to activate the nitrile functio