✦ LIBER ✦
ChemInform Abstract: Reaction of Phosphonium Ylides and Aromatic Nitriles under Lewis Acid Conditions: An Easy Access to Aryl-Substituted α-Methoxyacetophenones.
✍ Scribed by B. Camuzat-Dedenis; O. Provot; H. Moskowitz; J. Mayrargue
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 32 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0931-7597
No coin nor oath required. For personal study only.
✦ Synopsis
The title method for the synthesis of acetophenones of type (III), obtained in fair to good yields, is a good alternative to organometallic reactions. Lithium chloride, generated by deprotonation of the phosphonium salt with PhLi as base, probably acts as a Lewis acid to activate the nitrile function. -(CAMUZAT-DEDENIS, B.; PROVOT, O.;