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Fluorine in enzyme Chemistry: Part 1. Synthesis of difluoromethylenephosphonate derivatives as phosphate mimics

✍ Scribed by R.D. Chambers; R. Jaouhari; D. O'Hagan

Publisher: Elsevier Science
Year: 1989
Tongue: English
Weight: 443 KB
Volume: 44
Category: Article
ISSN: 0022-1139
DOI: 10.1016/s0022-1139(00)83944-5

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✦ Synopsis

Diethyl difluoromethylphosphonylcadmium bromide reacts with ally1 and benzyl halides in THF to give the corresponding difluoromethylenephosphonate derivatives . The reaction with ally1 bromide affords a versatile synthetic intermediate which undergoes a variety of synthetic transformations and therefore becomes a key compound in the preparation of elaborated difluoromethylenephosphonates of biological significance.

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